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NFL Week 1 lines: No big favorites

Three teams are 6.5-point favorites in opening lines for the 2022 NFL regular season released by sportsbooks with the 18-week game schedule finalized.

The NFL released a full schedule for the regular season on Thursday night, including the opening game of the season in Los Angeles between the Rams and Buffalo Bills. The Super Bowl champion Rams are a 1-point favorite at SoFi Stadium.

The AFC champion are 6.5-point favorites over the Pittsburgh Steelers in Week 1 and no team is a bigger favorite on the early lines.

San Francisco is a 6.5-point favorite at Chicago and the Tennessee Titans are 6.5-point favorites over the New York Giants.

The primetime games in Week 1 include Russell Wilson returning to Seattle with the Denver Broncos. Wilson's new crew is a 4-point favorite over the Seahawks on “Monday Night Football.”

Dallas is a home underdog on “Sunday Night Football.” The Cowboys are +2.5 against the Tampa Bay Buccaneers.

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